Soluble epoxide hydrolase‐derived linoleic acid diols, cerebral small vessel disease markers and white matter microstructural integrity in type 2 diabetes mellitus
In diabetes, LA-derived sEH diols were associated with greater cerebral small vessel disease pathology and white matter microstructural damage. sEH may be a potential therapeutic target to mitigate neurovascular and white matter damage in diabetes.
Authors
- Anthony E. Lang (ORCID: https://orcid.org/0000-0003-1229-3667)
- Bradley J. MacIntosh (ORCID: https://orcid.org/0000-0001-7300-2355)
- Stephen R. Arnott (ORCID: https://orcid.org/0000-0002-0616-7771)
- Robert A. Hegele (ORCID: https://orcid.org/0000-0003-2861-5325)
- Sean Symons (ORCID: https://orcid.org/0000-0002-8025-9965)
- Krista L. Lanctôt (ORCID: https://orcid.org/0000-0001-7024-6637)
- Malcolm A. Binns (ORCID: https://orcid.org/0000-0001-9998-6612)
- William Z. Lin (ORCID: https://orcid.org/0000-0002-3610-5213)
- Yong‐Chuan Wong
- Ameer Y. Taha
- Si Won Ryoo
- Myuri Ruthirakuhan
- Natasha Z. Anita
- Walter Swardfager
- Sandra E. Black
- Carmela Tartaglia
- Manuel Montero‐Odasso
Institutions
- Western University (CA)
- Lawson Health Research Institute (CA)
- Sunnybrook Health Science Centre (CA)
- University Health Network (CA)
- University of Toronto (CA)
- Heart and Stroke Foundation (CA)
- Toronto Western Hospital (CA)
- Health Sciences Centre (CA)
- Baycrest Hospital (CA)
- University of California San Diego (US)
- Toronto Dementia Research Alliance (CA)
- Public Health Ontario (CA)
- Indoc Research (CA)
- Sunnybrook Hospital (CA)
- Sunnybrook Research Institute
- University of California, Davis (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_104608
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00