Chronic alcohol consumption drives inflammaging and transposon derepression in hematopoietic stem and progenitor cells
Chronic alcohol consumption triggers age-dependent myeloid bias and inflammation in HSPCs without impairing self-renewalChronic alcohol consumption alters epigenome, driving heightened transposon upregulation in aged HSPCs.
Authors
- Haruna B. Choijilsuren (ORCID: https://orcid.org/0000-0002-7599-6207)
- Jung-Woo Kim (ORCID: https://orcid.org/0000-0001-8877-6556)
- Valerie Kellett
- Moonjung Jung (ORCID: https://orcid.org/0000-0002-1364-1814)
- Habin Bea
- Ridzky A. A. Yuda
- Li Luo
- Juhye Choi
- Fan Yang
- Yejie Park
- Yaojie Fu
- Sangmoo Jeong
- Zewen Ha
- Linda M. S. Resar
- Bin Gao
- Zhaoli Sun
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- National Institute on Alcohol Abuse and Alcoholism (US)
- Sidney Kimmel Comprehensive Cancer Center (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2025-12-26
- DOI
- https://doi.org/10.64898/2025.12.25.696246
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00