Exploring Synaptic Vesicle Glycoprotein 2A (SV2A) Alterations in Alzheimer's Disease Using Targeted Mass Spectrometry

These data are consistent with the reduction in SV2A PET signal in AD reflecting loss of synapses rather than loss of protein in remaining synapses. These data form part of the SV2A PET Project, a program of the FNIH Biomarker Consortium which together aim to understand the biological underpinnings of the change in SV2A PET signal in AD.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_103313
Primary Topic
Advanced Proteomics Techniques and Applications
Type
article
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article

Exploring Synaptic Vesicle Glycoprotein 2A (SV2A) Alterations in Alzheimer's Disease Using Targeted Mass Spectrometry

Henrik Zetterberg
Alzheimer s & Dementia
Advanced Proteomics Techniques and Applications
article

Exploring Synaptic Vesicle Glycoprotein 2A (SV2A) Alterations in Alzheimer's Disease Using Targeted Mass Spectrometry

Henrik Zetterberg
article en

Abstract

These data are consistent with the reduction in SV2A PET signal in AD reflecting loss of synapses rather than loss of protein in remaining synapses. These data form part of the SV2A PET Project, a program of the FNIH Biomarker Consortium which together aim to understand the biological underpinnings of the change in SV2A PET signal in AD.

Alzheimer s & DementiaVol. 21(S2)
University of Gothenburg (SE)
Good health and well-being
Openalex Percentile: Top 40%
Advanced Proteomics Techniques and Applications
DOIOpen Access PDFOpenAlex
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Exploring Synaptic Vesicle Glycoprotein 2A (SV2A) Alterations in Alzheimer's Disease Using Targeted Mass Spectrometry — Henrik Zetterberg · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS