Breaking Barriers in Alzheimer’s: Next‐Gen Small Molecules Targeting USP14 for Neuroprotection and Protein Homeostasis
This is the first report of IU1's use in AD models as a USP14 inhibitor. AA10 and AA51 showed superior efficacy, making them promising candidates for future preclinical validations. The next phase involves testing therapeutic efficacy and brain bioavailability in AD mouse models to advance their potential as future treatments.
Authors
- Prashant Bharadwaj (ORCID: https://orcid.org/0000-0003-4361-9906)
- Ajish Ariyath
- Ralph N Martins
- Warnakulasuriya Mary Ann Dipika Binosha Fernando
Institutions
- Edith Cowan University (AU)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_106289
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00