Pre‐morbid personality and personality changes in patients with the behavioral variant of Alzheimer's disease
BvADs had a pre-morbid personality comparable to bvFTDs and HCs, while tADs were characterized by higher warmth. After symptom onset, bvADs developed a rigid personality similar to bvFTD. These findings suggest that pre-morbid behavior could be a relevant factor for understanding development of divergent behavioral phenotypes emerging in response to neurodegeneration. Moreover, significant personality changes are not exclusive to bvFTD.
Authors
- Rik Ossenkoppele (ORCID: https://orcid.org/0000-0003-1584-7477)
- Elsmarieke van de Giessen
- Katherine Rankin
- David Soleimani‐Meigooni
- Faatimah Syed
- Argentina Lario Lago
- Fleur H.C. van der Linden
- Kaitlin B Casaletto
- Gil D. Rabinovici
Institutions
- University of California, San Francisco (US)
- University Memory and Aging Center (US)
- Amsterdam University Medical Centers (NL)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_105756
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00