Electroacupuncture alleviates central post-stroke pain in rats by modulating miR-21-5p/TGF-β/Smads pathway
These results indicate that the mechanisms underlying EA-induced analgesia involve downregulating miR-21-5p, consequently inhibiting neuroinflammation by regulating Smad7/TGF-β/Smads signaling pathway, providing a novel insight for probing the molecular mechanism of analgesic effect of EA.
Authors
- Nan An (ORCID: https://orcid.org/0000-0001-9197-4465)
- Guihua Tian (ORCID: https://orcid.org/0000-0002-5941-2945)
- H. Hao
- Ke He (ORCID: https://orcid.org/0009-0001-9812-8947)
- Youxiang Su
- Meiyue Wang
- Yang Wu
- Xinyi Li
- Luyu Yang
- Zhihao Shang
Institutions
- Peking University (CN)
- Peking University Cancer Hospital (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
- Peking University Third Hospital (CN)
- Beijing Friendship Hospital (CN)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-12-26
- DOI
- https://doi.org/10.1186/s10194-025-02247-1
- Primary Topic
- Acupuncture Treatment Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00