C‐Reactive Protein and Neutrophil‐To‐Lymphocyte Ratio: Can They Be Used Interchangeably in Tracking Clozapine‐Related Inflammation?

Our findings indicate that although NLR and other hematological indices are easily accessible and may provide some indication of inflammation, they cannot substitute for CRP in guiding clozapine titration decisions. Where CRP is unavailable, NLR > 3 may be cautiously informative, though CRP remains the preferred marker for early detection and dose adjustment to optimize tolerability, adherence, and safety during clozapine initiation.