Early Detection and Monitoring of Amyloid‐Related Imaging Abnormalities in Monoclonal Antibody Therapy Using Generalized Diffusion Basis Spectrum Imaging (g‐DBSI): A Pilot Study

Our findings suggest neuroinflammation's role in ARIA-E progression and demonstrate the potential of g-DBSI to detect microstructural changes before the onset of ARIA-E. This pilot study supports g-DBSI as a noninvasive imaging tool to monitor ARIA progression, providing insights into neuroinflammation and vasogenic edema. Further research with larger cohorts is necessary to further delineate and validate the potential clinical utility of g-DBSI.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_103007
Primary Topic
Intracerebral and Subarachnoid Hemorrhage Research
Type
article
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article

Early Detection and Monitoring of Amyloid‐Related Imaging Abnormalities in Monoclonal Antibody Therapy Using Generalized Diffusion Basis Spectrum Imaging (g‐DBSI): A Pilot Study

Eric McDade, Jorge J. Llibre‐Guerra, Meng Jiang, A. Atri et al.
Alzheimer s & Dementia
Intracerebral and Subarachnoid Hemorrhage Research
article

Early Detection and Monitoring of Amyloid‐Related Imaging Abnormalities in Monoclonal Antibody Therapy Using Generalized Diffusion Basis Spectrum Imaging (g‐DBSI): A Pilot Study

Eric McDade, Jorge J. Llibre‐Guerra, Meng Jiang, A. Atri, Nelly Joseph‐Mathurin, Qing Wang, Carlos Cruchaga, Guoqiao Wang, Yan Li, Jason J. Hassenstab, Chengjie Xiong, Yong Wang, Tammie L.S. Benzinger, Randall J. Bateman, Richard J. Perrin, David B. Clifford, Brian A. Gordon, the Dominantly Inherited Alzheimer Network Trials Unit Study Team, Laura Ibanez, Alan E. Renton
article en

Abstract

Our findings suggest neuroinflammation's role in ARIA-E progression and demonstrate the potential of g-DBSI to detect microstructural changes before the onset of ARIA-E. This pilot study supports g-DBSI as a noninvasive imaging tool to monitor ARIA progression, providing insights into neuroinflammation and vasogenic edema. Further research with larger cohorts is necessary to further delineate and validate the potential clinical utility of g-DBSI.

Alzheimer s & DementiaVol. 21(S2)
Washington University in St. Louis (US), Banner Health (US), Mallinckrodt (United States) (US), Hope Center for Neurological Disorders (US), Prevent Alzheimer’s Disease 2020 (US), Icahn School of Medicine at Mount Sinai (US)
Good health and well-being
Openalex Percentile: Top 31%
Intracerebral and Subarachnoid Hemorrhage Research
DOIOpen Access PDFOpenAlex
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Early Detection and Monitoring of Amyloid‐Related Imaging Abnormalities in Monoclonal Antibody Therapy Using Generalized Diffusion Basis Spectrum Imaging (g‐DBSI): A Pilot Study — Eric McDade, Jorge J. Llibre‐Guerra, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS