334P Modulation of myeloid cells by T cells activated by an IDO/PD-L1 vaccine reprograms the tumor micro-environment to support immune-mediated tumor killing
Conclusions: By combining multiple layers of tumor and immune data, our results suggest that resistance to chemo-ICI displays as a fibro-vascular reconfiguration of the tumor with macrophage infiltration responsible of immunosuppression.We identify potential therapeutic targets related to fibrosis, angiogenesis, macrophages, and PI3K pathway, to be tested in immune-based prospective clinical trials.
Authors
- Pedersen Aw
- T. Viet Luu
- A. Schina
- M.H. Andersen
- I. Lecoq Molinos
- M.O. Holmström
- I.M. Svane
- L. Rønn Olsen
- S.M. Ahmad
- E. Martinenaite
- M.M. Byrdal
Institutions
- University of Copenhagen (DK)
- Herlev Hospital (DK)
- Galecto (Denmark) (DK)
Publication Details
- Journal
- Immuno-Oncology Technology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.iotech.2025.101331
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Eli Lilly and Company
- AstraZeneca
- European Federation of Pharmaceutical Industries and Associations