Multidrug-Resistant <i>Campylobacter jejuni</i> Bacteremia Case Following Sheepskin Wrap Application

<b><i>Background:</i></b> <i>Campylobacter jejuni</i> typically causes gastrointestinal illness but may lead to severe systemic infection in immunocompromised hosts. Resistance to macrolides, fluoroquinolones, and tetracyclines is increasingly reported. <b><i>Case Presentation:</i></b> A 27-year-old male with X-linked agammaglobulinemia developed recurrent right foot cellulitis after local trauma. Following application of a non-sterile herbal ointment and sheepskin, the lesion progressed, and the patient developed fever and chills. Blood cultures repeatedly yielded multidrug-resistant <i>C. jejuni</i>, while wound culture grew <i>Citrobacter braakii</i>. The <i>C. jejuni</i> isolates showed high MICs to macrolides, fluoroquinolones, and tetracycline. Given persistent bacteremia despite broad-spectrum therapy, meropenem was initiated, resulting in rapid defervescence and clinical improvement. <b><i>Conclusion:</i></b> This case highlights the potential for transdermal acquisition of <i>C. jejuni</i> in immunodeficient patients, the clinical challenges posed by multidrug-resistant strains, and the need for education regarding traditional practices that may increase infection risk.