Carrying out a longitudinal multimodal biomarker study of late life depression and Alzheimer's disease risk: outreach and recruitment strategies

We employed a multi-faceted strategy integrating clinician referrals, advertisements, and partnership with registries to efficiently meet recruitment milestones. Challenges including limited enrollment of Hispanic/Latino or severely symptomatic individuals, and attitudes towards neuroimaging highlight the need to optimize methods to address health disparities. Future efforts including translation of study documents, expanded database queries, and options for non-imaging participation will improve outcomes and enhance understanding of depression and AD risk.