Omega Entropy from brain functional MRI is differentially associated with Cognitive performance
Higher cognitive scores in HVLT and MoCA were associated with lower DMN Ω, while higher HVLT total recall scores were associated with higher Ω in the limbic system. These results suggest more coherent brain activity in the DMN and less coherent activity in the Limbic system are associated with better cognitive performance. Our previous findings suggest Ω generally increases as we age, so especially the differential effect in the limbic system warrants further research. Overall Ω shows promise as a descriptor of cognitive states and needs to be further evaluated.
Authors
- Arijit Bhaumik (ORCID: https://orcid.org/0000-0001-6367-3075)
- Benjamin M. Hampstead (ORCID: https://orcid.org/0000-0003-2717-6375)
- David C. Zhu (ORCID: https://orcid.org/0000-0002-5264-0144)
- Henry L. Paulson (ORCID: https://orcid.org/0000-0002-0382-7535)
- Norman Scheel (ORCID: https://orcid.org/0000-0002-4641-7579)
- Jessica S. Damoiseaux
- Bruno Giordani
- Scott J. Peltier
- Jonathan M Reader
Institutions
- Albert Einstein College of Medicine (US)
- Wayne State University (US)
- University of Michigan (US)
- Michigan State University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103759
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00