Neuroanatomical predictors of tDCS current distribution in cognitively healthy older adults
Anatomical variability significantly influences the delivered tDCS current in the brain. Fat had a substantial negative relationship with J across ROIs, likely due to its insulating properties. Similarly, increased cortical volume was associated with decreased J likely due to its resistive properties, causing less current to enter into the intracranial space. Consistent with prior findings, more brain atrophy was associated with less J in the brain, due to current shunting within CSF. These insights underscore the necessity of accurately representing older adult anatomy to personalize tDCS application in older adults.
Authors
- Samantha Pedersen
- Adam J. Woods
- Skylar E. Stolte (ORCID: https://orcid.org/0000-0002-9300-1322)
- P. Shukla
- Yunfeng Dai (ORCID: https://orcid.org/0000-0003-3961-4766)
- Alejandro Albizu (ORCID: https://orcid.org/0000-0003-2727-6616)
- Aprinda Indahlastari (ORCID: https://orcid.org/0000-0002-5994-5514)
- Jason Chen (ORCID: https://orcid.org/0000-0003-1552-4352)
- Andrew O'Shea
- Ruogu Fang
- Kevin Iversen
- Tyler Ann Busch
- Gavin Hart
Institutions
- The University of Texas at Dallas (US)
- University of South Florida (US)
- University of Florida (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103172
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00