Peptides blocking ApoE pathological function safely reduce pathology in TgSwDI/apoE2, 3 and 4 AD mice
We have shown that diminishing Aβ binding to apoE and disrupting the pathological conformation of any apoE allele; significantly reduces Aβ pathology without secondary effects; constituting a safe and novel methodology to prevent early deposition and progression of Aβ pathology in AD Tg models, without associated ARIA like complications.
Authors
- Adam C. Mar (ORCID: https://orcid.org/0000-0002-2095-2936)
- Ding Wang (ORCID: https://orcid.org/0000-0002-4678-9954)
- Jie Lin (ORCID: https://orcid.org/0000-0003-2364-7993)
- Fernando R. Goñi
- Jasmine Okeagu
- Jianina Suazo
- Begonia Gamallo‐Lana
- Thomas Wisniewski
Institutions
- New York University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_102051
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00