The Role of the Temporoparietal Junction in Alzheimer's Disease
TPJ connectivity with other olfactory ROIs decreases with increasing amyloid pathology, which could result in olfactory dysfunction. The correlation between the interaction term and amyloid deposition was positive, but the significance was not strong may be due to the smaller sample size. Taken together, fMRI activity in the TPJ during olfactory fMRI is correlated with SUVr values in the brain, showing a brain-behavior relationship in MCI.
Authors
- Sangam Kanekar (ORCID: https://orcid.org/0000-0002-4192-7414)
- Paul J. Eslinger (ORCID: https://orcid.org/0000-0002-6032-7801)
- Jens Will
- Prasanna Karunanayaka (ORCID: https://orcid.org/0000-0002-1558-8981)
- Rommy Elyan
- Senal Peiris (ORCID: https://orcid.org/0009-0004-3684-0906)
- Katie Geesey
- Qing Yang
- Anupa Manjitha Ekanayake Mudiyanselage
Institutions
- Pennsylvania State University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103877
- Primary Topic
- Olfactory and Sensory Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00