172P Immune-related adverse events are immunologically distinct from classical autoimmune diseases: Evidence from broad autoantibody and complement profiling

Immune-related adverse events (irAEs) frequently mimic classical autoimmune diseases in their clinical presentation. However, whether they share similar immunopathogenic mechanisms remains unclear. This study aimed to systematically assess the contribution of autoantibodies and complement activation in patients developing irAEs without preexisting autoimmune diseases.

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Publication Details

Journal
Immuno-Oncology Technology
Published
2025-12-01
DOI
https://doi.org/10.1016/j.iotech.2025.101255
Primary Topic
Systemic Lupus Erythematosus Research
Type
article
Field-Weighted Citation Impact
0.00

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article

172P Immune-related adverse events are immunologically distinct from classical autoimmune diseases: Evidence from broad autoantibody and complement profiling

J. Vuille, M. Obeid, M. Torsello, N. Mederos Alfonso et al.
Immuno-Oncology Technology
Systemic Lupus Erythematosus Research
article

172P Immune-related adverse events are immunologically distinct from classical autoimmune diseases: Evidence from broad autoantibody and complement profiling

J. Vuille, M. Obeid, M. Torsello, N. Mederos Alfonso, S. Latifyan, L. Bennafla, L. Mencarelli, S. Peters, H. Bouchaab, N. Etienne, D. Daoudlarian, A. Stravodimou, A. Stamatiou, K. Shabafrouz
article en

Abstract

Immune-related adverse events (irAEs) frequently mimic classical autoimmune diseases in their clinical presentation. However, whether they share similar immunopathogenic mechanisms remains unclear. This study aimed to systematically assess the contribution of autoantibodies and complement activation in patients developing irAEs without preexisting autoimmune diseases.

Immuno-Oncology TechnologyVol. 28
Centre Hospitalier Universitaire Vaudois (CH)
Bristol-Myers Squibb, AstraZeneca, Helsinn, Regeneron Pharmaceuticals, Les Laboratories Pierre Fabre, Novo Nordisk, Odense Universitetshospital, Astellas Pharma, European Society for Medical Oncology
Good health and well-being
Openalex Percentile: Top 28%
Systemic Lupus Erythematosus Research
DOIOpen Access PDFOpenAlex
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172P Immune-related adverse events are immunologically distinct from classical autoimmune diseases: Evidence from broad autoantibody and complement profiling — J. Vuille, M. Obeid, et al. · Immuno-Oncology Technology (2025) | TGRS Research Map | TGRS