Comparisons of APOE‐ε4‐related Alzheimer's Disease Pathophysiology between Chinese and American Aging population

Less APOE-ε4 carriers were observed in Chinese older adults than in American older adults. However, more detrimental effects of APOE-ε4ε4 were found in plasma biomarkers, hippocampal atrophy, and cognitive decline among Chinese older adults than American older adults. These findings revealed the characteristics of the APOE-ε4 allele and its influence on AD pathophysiology among the Chinese and American aging population.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_101846
Primary Topic
Alzheimer's disease research and treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Comparisons of APOE‐ε4‐related Alzheimer's Disease Pathophysiology between Chinese and American Aging population

Laihong Zhang, Guoyu Lan, Dai Shi, Zhen Liu et al.
Alzheimer s & Dementia
Alzheimer's disease research and treatments
article

Comparisons of APOE‐ε4‐related Alzheimer's Disease Pathophysiology between Chinese and American Aging population

Laihong Zhang, Guoyu Lan, Dai Shi, Zhen Liu, Tengfei Guo, Mingxing Jiang, Anqi Li
article en

Abstract

Less APOE-ε4 carriers were observed in Chinese older adults than in American older adults. However, more detrimental effects of APOE-ε4ε4 were found in plasma biomarkers, hippocampal atrophy, and cognitive decline among Chinese older adults than American older adults. These findings revealed the characteristics of the APOE-ε4 allele and its influence on AD pathophysiology among the Chinese and American aging population.

Alzheimer s & DementiaVol. 21(S2)
Sun Yat-sen University (CN), The Seventh Affiliated Hospital of Sun Yat-sen University (CN), Shenzhen Bay Laboratory (CN), Peking University Shenzhen Hospital (CN)
Openalex Percentile: Top 33%
Alzheimer's disease research and treatments
DOIOpen Access PDFOpenAlex
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Comparisons of APOE‐ε4‐related Alzheimer's Disease Pathophysiology between Chinese and American Aging population — Laihong Zhang, Guoyu Lan, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS