Orbital Retinoblastoma: From Palliation to Cure by Sequential Multimodal Multidisciplinary Therapy – A Case Report

This case underscores the importance of multimodal combination therapy in improving survival outcomes, highlighting the promising impact of neoadjuvant systemic chemotherapy in reducing tumour burden even in advanced RB. It also draws attention to the use of PBT as a superior alternative to conventional external beam radiotherapy, due to its ability to reduce dose splash to surrounding organs, reducing the chance of secondary malignancies [Indian J Ophthalmol. 2024;72(6):778-88]. Above all, this case challenges the historical prognosis of orbital RB, demonstrating that with a tailored and comprehensive approach, even children with advanced disease can attain disease-free survival. It serves as a call to action for the clinical community to continue pursuing evidence-based treatment protocols that can transform advanced RB care.