Myelin Changes in APPSweLon Mouse Model Detected by Diffusion MRI and X‐ray Scattering Tomography

Imaging changes suggesting compromised myelin levels were detected in AD mice white matter and gray matter compared to controls. White matter changes were better detected with diffusion MR imaging. Gray matter changes were detected only using X-ray scattering, not MRI, presumably due to the complexity of gray matter microstructure with many features besides myelin influencing diffusion MRI signal. X-ray scattering may thus detect subtle degenerative myelin changes in regions where MRI methods show lower sensitivity.