Plasma biomarkers of neuroinflammation and neurodegeneration in relation to cerebral glucose hypometabolism in autosomal‐dominant Alzheimer's disease
Our data suggest that the FDG-PET signal may reflect both reactive astrogliosis and neuronal injury in AD, with the effect of reactive astrogliosis on hypometabolism being independent of neurodegeneration. With astrocytes interfacing neurovascular communication, underlying vascular or neuroinflammatory mechanisms could contribute to hypometabolism and early disease onset, calling for a more cautious interpretation of brain FDG-PET imaging.
Authors
- Ana Baena (ORCID: https://orcid.org/0000-0002-5622-4519)
- Rosalinda Medrano
- Bernard Hanseeuw (ORCID: https://orcid.org/0000-0002-3102-6778)
- Mónica Vidal (ORCID: https://orcid.org/0000-0003-2003-7954)
- Yakeel T. Quiroz (ORCID: https://orcid.org/0000-0001-9714-8244)
- Catarina Tristão‐Pereira (ORCID: https://orcid.org/0000-0001-9660-8341)
- Vincent Malotaux (ORCID: https://orcid.org/0000-0003-0737-9220)
- Nikole A Bonillas Félix
- Sergio Castro Álvarez
- David Fernando Aguillón Niño (ORCID: https://orcid.org/0000-0003-2283-536X)
- Edmarie Guzman‐Velez
- Clara Vila‐Castelar
- Natalia Londono
- Steven E Arnold
- Bing He
- Eric M. Reiman
- Averi Giudicessi
- Lusiana Martinez
Institutions
- Boston University (US)
- Harvard University (US)
- Universidad de Antioquia (CO)
- Massachusetts General Hospital (US)
- Hospital Pablo Tobon Uribe (CO)
- Banner Alzheimer’s Institute
- UCLouvain (BE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_103647
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00