Understanding the mechanisms linking GDF15 to dementia risk: A translational approach
GDF15's relationship with dementia risk may be explained by its effects on macrophages and other peripheral myeloid cells. By attenuating interferon signaling and heme scavenging and increasing pyruvate metabolism, plasma GDF15 may increase dementia risk.
Authors
- Ranjan Sen (ORCID: https://orcid.org/0000-0001-5693-787X)
- Jingsha Chen
- Mary Kaileh (ORCID: https://orcid.org/0000-0003-2314-312X)
- Yevgeniya Lukyanenko (ORCID: https://orcid.org/0000-0003-2096-2971)
- Christie Mitchell Ballantyne (ORCID: https://orcid.org/0000-0002-6432-1730)
- Michael R. Duggan (ORCID: https://orcid.org/0000-0002-1029-4423)
- Alexey E. Lyashkov
- Dimitrios Tsitsipatis
- Keenan A. Walker (ORCID: https://orcid.org/0000-0002-5989-9853)
- Krystyna Mazan‐Mamczarz
- M Gorospe
- Aditi Gupta (ORCID: https://orcid.org/0000-0003-1246-9503)
- Cassandra Blew
- Cassandra M Joynes
- Alison B Herman
- Rebecca F. Gottesman
- Michael E. Griswold
Institutions
- National Institutes of Health (US)
- Johns Hopkins University (US)
- Baylor College of Medicine (US)
- Jackson Memorial Hospital (US)
- University of Mississippi Medical Center (US)
- National Institute of Neurological Disorders and Stroke (US)
- Institute on Aging (US)
- National Institute on Aging (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106820
- Primary Topic
- GDF15 and Related Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00