Widespread DNA double strand break and repair events excise most of APOE exon 4 in Alzheimer's disease
Our data reveal that APOE is subject to widespread double-strand break and repair events excising key APOE risk variants in the process. These data have profound implications for APOE function and our understanding of the mechanism underlying APOE risk.
Authors
- Evangelos Nizamis
- T. Bird
- Daniel D. Child (ORCID: https://orcid.org/0000-0002-4309-0144)
- Eli J. Kaufman (ORCID: https://orcid.org/0000-0001-8553-210X)
- Caitlin S. Latimer (ORCID: https://orcid.org/0000-0003-3727-4278)
- Julianna N. Brutman (ORCID: https://orcid.org/0000-0001-9230-3647)
- Tina Busald
- C. P. Johnson
- Samuel N. Smukowski
- Suman Jayadev (ORCID: https://orcid.org/0000-0003-3164-9665)
- Paul N. Valdmanis (ORCID: https://orcid.org/0000-0001-8840-6969)
- Marissa J de Leon
- Katherine E Prater
Institutions
- University of Washington (US)
- VA Puget Sound Health Care System (US)
- Geriatric Research Education and Clinical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105919
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00