Associations of Sleep Quality and Apolipoprotein Genotype with Blood‐based Biomarkers of Alzheimer's Disease and Neurodegeneration
As elevated pTau231 levels may be associated with the development and progression of AD, poor SQ may also be linked to early stages of these processes. These results cannot address direction of causation, but for individuals at lower genetic risk for AD based on APOE, poorer SQ might represent an alternative pathway influencing AD pathogenesis. If so, these findings underscore the importance of addressing SQ as a modifiable risk factor that may reduce the risk of AD and they highlight the need to consider genetic risk when examining SQ.
Authors
- Christine Fennema‐Notestine (ORCID: https://orcid.org/0000-0002-6527-6361)
- Jeremy A. Elman (ORCID: https://orcid.org/0000-0002-5840-1769)
- Robert A. Rissman (ORCID: https://orcid.org/0000-0001-9245-8278)
- William S. Kremen (ORCID: https://orcid.org/0000-0002-8629-5609)
- Tina Vo
- Nathan A. Gillespie (ORCID: https://orcid.org/0000-0001-8655-2823)
- Michael J. Lyons (ORCID: https://orcid.org/0000-0001-6516-9219)
- Carol E. Franz (ORCID: https://orcid.org/0000-0002-8987-1755)
- Chandra A Reynolds
- Matthew S. Panizzon
Institutions
- University of Southern California (US)
- Autism Research Institute (US)
- Virginia Commonwealth University (US)
- University of Colorado Boulder (US)
- University of California San Diego (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_099180
- Primary Topic
- Sleep and related disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00