fMRI‐Complexity as a potential presymptomatic predictor of cognitive decline in Alzheimer's Disease
The converter groups showed significantly altered fMRI-complexity while the stable groups showed no significant effect. These results demonstrate that fMRI-complexity is sensitive to early presymptomatic changes in subjects that will transition from one stage to a more severe disease stage. This suggests that MSE could contribute to early diagnosis, prognostic monitoring and eventually precision care for Alzheimer's disease.
Authors
- Dilmini Wijesinghe (ORCID: https://orcid.org/0000-0002-2696-6781)
- Steven Cen (ORCID: https://orcid.org/0000-0002-7859-8909)
- Ru Zhang (ORCID: https://orcid.org/0009-0001-9122-0556)
- Kirsten M. Lynch (ORCID: https://orcid.org/0000-0003-3976-5783)
- Kay Jann
- ADNI
- Jared Brown
Institutions
- University of Southern California (US)
- California State University, Fullerton (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_098460
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00