Obesity Reduces Endometrial Receptivity by Downregulating the Ob-Rb/STAT-3 Signaling Pathway in Women and Female Mice
Obesity-induced Ob-Rb/STAT-3 signaling dysfunction is a central mechanism impairing endometrial receptivity. Leptin resensitization via weight loss partially reverses these effects, suggesting potential therapies for targeting leptin resistance or Ob-Rb/STAT-3 signaling in obesity-related infertility.
Authors
- Panshi Xie (ORCID: https://orcid.org/0000-0002-7190-3288)
- Zhaolian Wei (ORCID: https://orcid.org/0009-0006-0778-8787)
- L.A. Wang
- Gen F. Tang
- Caihua Li
- Youyan Fang
- Peipei Guo
- Yunxia Cao
- Yi Wang
- Ye He
- Wanlu Wang
Institutions
- Anhui University (CN)
- Bengbu Medical College (CN)
- Anhui Medical University (CN)
- Anhui Provincial Hospital (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- The Second Affiliated Hospital of Bengbu Medical College (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
Publication Details
- Journal
- Journal of the Endocrine Society
- Published
- 2025-12-22
- DOI
- https://doi.org/10.1210/jendso/bvaf220
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Anhui Province