Subjective Cognitive Decline and Minor Neuropsychological Deficits: Importance for Risk Stratification and Trial Recruitment in Early Alzheimer´s Disease
SCD and MNPD have a complementary prognostic value. SCD+/MNPD+ individuals are at particularly high risk of pathology and decline. These clinical symptoms should be taken into account in the recruitment for clinical trials in preclinical AD.
Authors
- Anja Schneider (ORCID: https://orcid.org/0000-0002-3377-5828)
- Robert Perneczky (ORCID: https://orcid.org/0000-0003-1981-7435)
- Annika Spottke (ORCID: https://orcid.org/0000-0001-9854-2972)
- Elizabeth Kuhn (ORCID: https://orcid.org/0000-0002-3744-1155)
- Christoph Laske (ORCID: https://orcid.org/0009-0009-3434-936X)
- Luca Kleineidam (ORCID: https://orcid.org/0009-0006-3309-6856)
- H Boecker
- Katharina Büerger (ORCID: https://orcid.org/0000-0002-5898-9953)
- Marcel Daamen (ORCID: https://orcid.org/0000-0002-3017-3901)
- Melina Stark (ORCID: https://orcid.org/0009-0005-3812-023X)
- Josef Priller
- Frederic Brosseron
- Jens Wiltfang
- Matthias Schmid
- Emrah Düzel
- Frank Jessen
- Stefan J. Teipel
- Oliver Peters
- Michael Wagner
Institutions
- University of Bonn (DE)
- University of Cologne (DE)
- University Hospital Bonn (DE)
- German Center for Neurodegenerative Diseases (DE)
- LMU Klinikum (DE)
- Zimmer Biomet (Germany) (DE)
- Munich Cluster for Systems Neurology (DE)
- UK Dementia Research Institute (GB)
- Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases (DE)
- Hertie Institute for Clinical Brain Research (DE)
- University of Rostock (DE)
- Imperial College London (GB)
- University of Aveiro (PT)
- Technical University of Munich (DE)
- University of Göttingen (DE)
- Charité - Universitätsmedizin Berlin (DE)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
- University of Edinburgh (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_102815
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00