ProtBAG: Eleven organ‐specific proteome‐based biological age using CSF proteomics
This study leverages CSF proteomics data from ADNI to accurately develop 11 organ-specific ProtBAGs, enriching the organ aging clock framework established in previous literature using plasma proteomics. Future research will investigate the relationship between these ProtBAGs, cognition, and AD progression.
Authors
- Donald Edmondson (ORCID: https://orcid.org/0000-0002-4518-8196)
- Toga Aw
- Hui Cao (ORCID: https://orcid.org/0000-0002-5901-5499)
- Wang Gao (ORCID: https://orcid.org/0000-0002-3827-2111)
- A. Zalesky
- Wenjia Bai
- Mehrshad Saadatinia
- Elisa Konofagou
- Ye Ella Tian
- Junhao Wen
- Sarah Ko
Institutions
- University of Southern California (US)
- The University of Melbourne (AU)
- New York Genome Center (US)
- Fujitsu (United Kingdom) (GB)
- Melbourne Health (AU)
- Columbia University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_101793
- Primary Topic
- Advanced Proteomics Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00