Wake slow waves during resting‐state EEG vary with current and two‐year changes in amyloid and neurodegeneration status in older adults with memory complaints

Our findings suggest that wSW features may serve as early EEG biomarkers for amyloid deposition and neurodegeneration in AD. These metrics, measurable during a simple and brief resting-state EEG, show potential for identifying at-risk individuals at very early stages of the disease, even before cognitive decline onset.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_101063
Primary Topic
Sleep and Wakefulness Research
Type
article
Field-Weighted Citation Impact
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article

Wake slow waves during resting‐state EEG vary with current and two‐year changes in amyloid and neurodegeneration status in older adults with memory complaints

Rubén Herzog, D. Oudiette, Isabelle Arnulf, Filipa Raposo Pereira et al.
Alzheimer s & Dementia
Sleep and Wakefulness Research
article

Wake slow waves during resting‐state EEG vary with current and two‐year changes in amyloid and neurodegeneration status in older adults with memory complaints

Rubén Herzog, D. Oudiette, Isabelle Arnulf, Filipa Raposo Pereira, Thomas Andrillon, Pierre Champetier, Claudia Albero, Marion Houot, Nathalie George, INSIGHT‐preAD group, Maximilien Chaumon
article en

Abstract

Our findings suggest that wSW features may serve as early EEG biomarkers for amyloid deposition and neurodegeneration in AD. These metrics, measurable during a simple and brief resting-state EEG, show potential for identifying at-risk individuals at very early stages of the disease, even before cognitive decline onset.

Alzheimer s & DementiaVol. 21(S2)
Centre National de la Recherche Scientifique (FR), Inserm (FR), Université Sorbonne Nouvelle (FR), Sorbonne Université (FR), University Memory and Aging Center (US), Pitié-Salpêtrière Hospital (FR), Institut de Psychiatrie et Neurosciences de Paris (FR)
Openalex Percentile: Top 32%
Sleep and Wakefulness Research
DOIOpen Access PDFOpenAlex
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Wake slow waves during resting‐state EEG vary with current and two‐year changes in amyloid and neurodegeneration status in older adults with memory complaints — Rubén Herzog, D. Oudiette, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS