Integrative cross‐omics analysis identifies DNA methylation signatures associated with bilateral hippocampal volume, asymmetry and atrophy rate in the general population
Our findings reveal methylation signatures as potential biomarkers or therapeutic targets for age- or neurodegeneration-related hippocampal atrophy. They further underscore the influence of modifiable dietary patterns on methylation and hippocampal health.
Authors
- J. Wardlaw
- Robin Bülow (ORCID: https://orcid.org/0000-0003-1884-5784)
- Karen A. Mather (ORCID: https://orcid.org/0000-0003-4143-8941)
- Dina Vojinović (ORCID: https://orcid.org/0000-0001-5744-0232)
- Perminder Singh Sachdev (ORCID: https://orcid.org/0000-0002-9595-3220)
- Santiago Estrada (ORCID: https://orcid.org/0000-0003-0339-8870)
- Mohammed Aslam Imtiaz
- Marian Beekman (ORCID: https://orcid.org/0000-0003-0585-6206)
- Monique M.B. Breteler (ORCID: https://orcid.org/0000-0002-0626-9305)
- Simon R. Cox (ORCID: https://orcid.org/0000-0003-4036-3642)
- Wittfeld Katharina
- Nicola J. Armstrong (ORCID: https://orcid.org/0000-0002-4477-293X)
- Dan Liu (ORCID: https://orcid.org/0000-0002-6732-7433)
- Natalie A. Royle
- Juliana F. Tavares (ORCID: https://orcid.org/0000-0001-5659-1864)
- Valentina Talevi (ORCID: https://orcid.org/0000-0003-4418-7439)
- Konstantinos Melas (ORCID: https://orcid.org/0009-0000-5206-5322)
- Alexander Teumer
- Ruiqi Wang
- P. Eline Slagboom
- Qiong Yang
- Hans J. Grabe
- Wei Wen
- Henry Voelzke
- N. Ahmad Aziz
- Robert Francis Hillary
Institutions
- Boston University (US)
- NHS Lothian (GB)
- University of Bonn (DE)
- Curtin University (AU)
- Universitätsmedizin Greifswald (DE)
- Leiden University Medical Center (NL)
- German Center for Neurodegenerative Diseases (DE)
- Erasmus MC (NL)
- UNSW Sydney (AU)
- Institut für Medizinische Biometrie, Informatik und Epidemiologie (DE)
- Ixico (United Kingdom) (GB)
- ARC Centre of Excellence in Synthetic Biology (AU)
- UK Dementia Research Institute (GB)
- German Centre for Cardiovascular Research (DE)
- University of Edinburgh (GB)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_099862
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00