Behavioral Analysis and MRI Findings in a CAA Mouse Model with Chronic Cerebral Hypoperfusion

Chronic cerebral hypoperfusion in EC-APP770+ mice may accelerate disease progression, suggesting that the combination of CAA and hypoperfusion can exacerbate cognitive decline. Given that CAA patients often present with concomitant atherosclerotic changes, this mouse model of chronic hypoperfusion may serve as a valuable tool for studying the pathophysiology of CAA patients coexisting arteriosclerosis.