Exploring the Effects of Phospholipase A2 Inhibition on Brain Metabolism and Pathology in a Rat Model of Alzheimer’s Disease
These findings indicate choline concentration is associated with PLA2 activity in AD. However, changes to spatial memory formation with PLA2 inhibition were not observed. This is contrary to the literature; thus, further research is needed to understand if PLA2 plays a role in AD associated memory impairment.
Authors
- Colleen Bailey (ORCID: https://orcid.org/0000-0002-7707-867X)
- JoAnne McLaurin
- Tina L. Beckett
- Wendy Oakden
- Jamie Near
- Mary Hill
- Emily Hiles
Institutions
- Sunnybrook Health Science Centre (CA)
- University of Toronto (CA)
- Sunnybrook Hospital (CA)
- Sunnybrook Research Institute
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_103238
- Primary Topic
- Neurological Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00