Elevated cerebral pulsatility is associated with cerebrospinal fluid biomarkers of neurodegeneration in cognitively unimpaired adults

Overall, elevated cerebral PI, measured with 4D flow MRI, was associated with CSF biomarkers of neurodegeneration and synaptic dysfunction in cognitively unimpaired middle-aged and older adults. As such, cerebral pulsatility may represent an early biomarker for AD risk and interventions that target cerebral pulsatility may mitigate neurodegeneration.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70856_104246
Primary Topic
Neurological Disease Mechanisms and Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Elevated cerebral pulsatility is associated with cerebrospinal fluid biomarkers of neurodegeneration in cognitively unimpaired adults

Jill N. Barnes, Alexander M. Norby, Anna J. Howery, Nicole A. Loggie et al.
Alzheimer s & Dementia
Neurological Disease Mechanisms and Treatments
article

Elevated cerebral pulsatility is associated with cerebrospinal fluid biomarkers of neurodegeneration in cognitively unimpaired adults

Jill N. Barnes, Alexander M. Norby, Anna J. Howery, Nicole A. Loggie, Oliver Wieben, Brandon G. Fico, Gwendlyn Kollmorgen, Kaj Blennow, M. Erin Moir, Henrik Zetterberg, Sarean Harmoni A. Gaynor‐Metzinger, Sterling C Johnson
article en

Abstract

Overall, elevated cerebral PI, measured with 4D flow MRI, was associated with CSF biomarkers of neurodegeneration and synaptic dysfunction in cognitively unimpaired middle-aged and older adults. As such, cerebral pulsatility may represent an early biomarker for AD risk and interventions that target cerebral pulsatility may mitigate neurodegeneration.

Alzheimer s & DementiaVol. 21(S2)
University of Wisconsin–Madison (US), Hong Kong Science and Technology Parks Corporation (HK), Sahlgrenska University Hospital (SE), Roche Pharma AG (Germany) (DE), UK Dementia Research Institute (GB), University College London (GB), Florida Atlantic University (US), University of Gothenburg (SE)
Openalex Percentile: Top 38%
Neurological Disease Mechanisms and Treatments
DOIOpen Access PDFOpenAlex
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Elevated cerebral pulsatility is associated with cerebrospinal fluid biomarkers of neurodegeneration in cognitively unimpaired adults — Jill N. Barnes, Alexander M. Norby, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS