Tumor-associated Pancreatitis Mimicking Autoimmune Pancreatitis in a Young Male: A Case of Main Duct IPMC

We report a rare case of intraductal papillary mucinous carcinoma (IPMC) in a young male who initially presented with imaging findings suggestive of autoimmune pancreatitis (AIP) and was later diagnosed with tumor-associated pancreatitis. Despite symptom resolution with conservative treatment, follow-up imaging revealed a pancreatic tumor. Surgical resection confirmed the presence of IPMC with adenocarcinoma components. This case highlights the importance of excluding malignancy even in young patients with AIP-like features. Given the limited sensitivity of FDG-PET for early stage tumors, adjunctive modalities such as endoscopic ultrasound (EUS) and serial pancreatic juice aspiration cytological examination (SPACE) should be actively considered.

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Publication Details

Journal
Internal Medicine
Published
2025-12-24
DOI
https://doi.org/10.2169/internalmedicine.6037-25
Primary Topic
IgG4-Related and Inflammatory Diseases
Type
article
Field-Weighted Citation Impact
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article

Tumor-associated Pancreatitis Mimicking Autoimmune Pancreatitis in a Young Male: A Case of Main Duct IPMC

Kenji Nakagawa, Koji Ishida, Noriyuki Hamato, Toshiya Nakatani et al.
Internal Medicine
IgG4-Related and Inflammatory Diseases
article

Tumor-associated Pancreatitis Mimicking Autoimmune Pancreatitis in a Young Male: A Case of Main Duct IPMC

Kenji Nakagawa, Koji Ishida, Noriyuki Hamato, Toshiya Nakatani, Masato Nakatsuji, Mariya Kawanishi, Akitoshi Douhara, Masahiro Tsutsumi
article en

Abstract

We report a rare case of intraductal papillary mucinous carcinoma (IPMC) in a young male who initially presented with imaging findings suggestive of autoimmune pancreatitis (AIP) and was later diagnosed with tumor-associated pancreatitis. Despite symptom resolution with conservative treatment, follow-up imaging revealed a pancreatic tumor. Surgical resection confirmed the presence of IPMC with adenocarcinoma components. This case highlights the importance of excluding malignancy even in young patients with AIP-like features. Given the limited sensitivity of FDG-PET for early stage tumors, adjunctive modalities such as endoscopic ultrasound (EUS) and serial pancreatic juice aspiration cytological examination (SPACE) should be actively considered.

Internal Medicine
Jikei University Kashiwa hospital (JP), Yamato Municipal Hospital (JP)
Good health and well-being
Openalex Percentile: Top 28%
IgG4-Related and Inflammatory Diseases
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