Multicohort characterization of brain volume and cognitive decline in LATE‐NC cases with or without Alzheimer's disease pathology

In a large, multicohort study, AD and LATE-NC uniquely were associated with MTL volume and cognitive decline. Characterizing the clinical correlates of LATE-NC is essential to identifying LATE-NC during life and supporting future research into its pathogenesis.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70857_107276
Primary Topic
Dementia and Cognitive Impairment Research
Type
article
Field-Weighted Citation Impact
0.00
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Multicohort characterization of brain volume and cognitive decline in LATE‐NC cases with or without Alzheimer's disease pathology

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Alzheimer s & Dementia
Dementia and Cognitive Impairment Research
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Multicohort characterization of brain volume and cognitive decline in LATE‐NC cases with or without Alzheimer's disease pathology

Michael Cuccaro, Timothy J. Hohman, Renaud La Joie, Sarah Biber, Gary W. Beecham, Derek B. Archer, Logan C. Dumitrescu, Christos A. Davatzikos, Leslie S. Gaynor, Phoebe Scollard, Alaina Durant, Lisa Laverne Barnes, Seo‐Eun Choi, Walter W. Kukull, Guray Erus, Angela L. Jefferson, Paul K Crane, Thomas J. Montine, Shubhabrata Mukherjee, Julie A Schneider, Shannon L Risacher, David A. A. Bennett, Mohamad Habes, Yuhan Cui, Michael L. Lee
article en

Abstract

In a large, multicohort study, AD and LATE-NC uniquely were associated with MTL volume and cognitive decline. Characterizing the clinical correlates of LATE-NC is essential to identifying LATE-NC during life and supporting future research into its pathogenesis.

Alzheimer s & DementiaVol. 21(S3)
Rush University Medical Center (US), University of Miami (US), Université de Bordeaux (FR), Inserm (FR), The University of Texas at San Antonio Health Science Center (US), University of California, San Francisco (US), University of Washington (US), Bordeaux Population Health (FR), Indiana University School of Medicine, The University of Texas at San Antonio (US), Wake Forest University (US), Indiana University – Purdue University Indianapolis (US), University of Pennsylvania (US), Vanderbilt University Medical Center (US), Stanford University (US)
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Openalex Percentile: Top 33%
Dementia and Cognitive Impairment Research
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