A Digital Atlas to Unlock the Potential of Brain Biorepository Tissue for Interdisciplinary Research
The digital BSP atlas provides an explicit spatial representation of the BSP, enabling researchers to more efficiently locate, reference, and utilize postmortem samples. Implementing the BSP with modern neuroinformatics conventions provides a highly portable, quantitative reference that facilitates interdisciplinary collaboration, dynamic visualization, figure generation, protocol optimization, and integration with in-vivo neuroimaging. Ongoing extensions of this work include the development of neuropathology sampling training software and a flexible interface to identify corresponding samples from free-form neuroscience terms.
Authors
- Caitlin S. Latimer (ORCID: https://orcid.org/0000-0003-3727-4278)
- Thomas J. Grabowski (ORCID: https://orcid.org/0000-0002-7425-6610)
- Jason Webster
- Yiqin Alicia Shen (ORCID: https://orcid.org/0000-0002-7138-9290)
- Ali Shojaie (ORCID: https://orcid.org/0009-0000-7463-2914)
- Tung Thanh Le (ORCID: https://orcid.org/0000-0003-1564-4362)
- Christine MacDonald
- C. Dirk Keene
Institutions
- University of Washington (US)
- Neurological Surgery (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107778
- Primary Topic
- Cell Image Analysis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00