The Association between Sleep Disturbances, Imaging Biomarkers and Cognitive Decline along the Trajectory of Alzheimer's Disease

This study demonstrates that sleep disturbances significantly contribute to tau burden and cognitive decline in AD, with SDB exhibiting an earlier and more pronounced impact than insomnia. These findings highlight the importance of targeting sleep disturbances to mitigate tau-related pathology, protect cognitive function, and slow disease progression. Early diagnosis and targeted interventions for sleep disturbances could provide significant therapeutic benefits in managing AD and improving patient outcomes.