Comprehensive Analysis of MTHFR Polymorphisms in the TATA Longitudinal Study of Aging Cohort

This study provides important new insights into the genetic architecture of MTHFR variants in an elderly Indian population, paving the way for further research aimed at mitigating cognitive decline associated with aging. The identification of a significant association between the intronic variant 1:11793135 and elevated homocysteine levels suggests a potential genetic predisposition to altered homocysteine metabolism in aging individuals. These findings emphasize the importance of genetic screening for MTHFR polymorphisms in at-risk populations and highlight the need for targeted nutritional and pharmacological interventions to regulate homocysteine levels.