Structure of γ‐secretase‐Ab46 complex: insights into amyloid‐β processing and modulation by the APH‐1B isoform
These findings advance our understanding of the proteolytic mechanisms of GSEC, which is important for the further development of GSEC inhibitors and modulators in cancer and Alzheimer's disease therapies.
Authors
- Lucía Chávez‐Gutiérrez (ORCID: https://orcid.org/0000-0002-8239-559X)
- Rouslan G. Efremov (ORCID: https://orcid.org/0000-0001-7516-8658)
- Mohamed Belal Hamed (ORCID: https://orcid.org/0000-0002-6383-4147)
- Ivica Odorčić (ORCID: https://orcid.org/0000-0002-8121-3803)
Institutions
- VIB-KU Leuven Center for Microbiology (BE)
- VIB-VUB Center for Structural Biology (BE)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_105954
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00