Sex Differences in Neuropsychiatric Symptoms Associated with Agitation in Frontotemporal Lobar Degeneration
This study reveals significant sex differences in NPS in FTLD-related syndromes when agitation is present. Males and especially PSP, are more likely to experience a broader range of NPS in association with agitation. These findings underscore the need for further investigation into the underlying mechanisms driving these sex differences, particularly focusing on the neurobiological impact of agitation, the recognition of symptoms in the presence of greater behavioral disturbances, and potential variations from informant reports. Understanding these factors will provide valuable insights into the role of agitation in the presentation of NPS across FTLD-related syndromes. Ultimately, addressing these gaps will enhance our ability to effectively treat and manage agitation in both male and female patients with FTLD-related syndromes.
Authors
- Hilary W. Heuer (ORCID: https://orcid.org/0000-0002-3776-1685)
- Erin M. Ramos (ORCID: https://orcid.org/0000-0002-2210-325X)
- Belén Pascual (ORCID: https://orcid.org/0000-0002-4467-7406)
- Joseph C. Masdeu (ORCID: https://orcid.org/0000-0001-9955-6954)
- Ian Grant (ORCID: https://orcid.org/0000-0001-6960-6762)
- Yann Cobigo (ORCID: https://orcid.org/0000-0002-0354-4092)
- Juan‐Camilo Vargas‐González (ORCID: https://orcid.org/0000-0002-1719-2200)
- Ian R. Mackenzie (ORCID: https://orcid.org/0000-0003-3875-2972)
- Emily Rogalskı (ORCID: https://orcid.org/0000-0002-6472-1363)
- Ging‐Yuek Robin Hsiung (ORCID: https://orcid.org/0000-0002-8017-0856)
- Andrea Bozoki (ORCID: https://orcid.org/0000-0002-4899-9381)
- Sami J. Barmada (ORCID: https://orcid.org/0000-0002-9604-968X)
- M MENDEZ
- Leah K. Forsberg (ORCID: https://orcid.org/0000-0003-4086-9598)
- Brian S. Appleby (ORCID: https://orcid.org/0000-0003-2275-3292)
- Erik D. Roberson (ORCID: https://orcid.org/0000-0002-1810-9763)
- Nupur Ghoshal (ORCID: https://orcid.org/0000-0002-6680-6731)
- Gabriel C. Léger (ORCID: https://orcid.org/0000-0001-7900-3957)
- Chiadi Onyike
- Peter Pressman (ORCID: https://orcid.org/0000-0003-1760-1286)
- Ryan Darby
- Carmela M. Tartaglia
- Kasey Cortez
- Brad F Boeve
- Irene Litvan
- Brad C. Dickerson
- Nico Paulo Dimal
- Lawrence S. Honig
- Celine N. Sakran
- Daniel H. Geschwind
- David G. Clark
- Adam L. Boxer
- Douglas R. Galasko
- Kejal Kantarci
- David J. Irwin
- Kimiko Domoto‐Reilly
- Neill R. Graff‐Radford
- Howard J. Rosen
Institutions
- Northwestern University (US)
- University of North Carolina at Chapel Hill (US)
- Alzheimer's Association (US)
- Houston Methodist (US)
- University Health Network (CA)
- Harvard University (US)
- University of British Columbia (CA)
- Johns Hopkins University (US)
- University of California, Los Angeles (US)
- University of California, San Francisco (US)
- University of Toronto (CA)
- University of Washington (US)
- Washington University in St. Louis (US)
- University of Michigan (US)
- Toronto Western Hospital (CA)
- Columbia University Irving Medical Center (US)
- Johns Hopkins Medicine (US)
- Jacksonville College (US)
- University of Alabama at Birmingham (US)
- University of California San Diego (US)
- Massachusetts General Hospital (US)
- Toronto Dementia Research Alliance (CA)
- University Memory and Aging Center (US)
- Occupational Cancer Research Centre (CA)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- University School (US)
- Ontario Brain Institute (CA)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- Case Western Reserve University (US)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70857_103036
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00