Integrated single‐nucleus and spatial analysis of PS19 tauopathy mice finds aberrant neuronal to glial communication is ameliorated by neurotrophin modulator LM11A‐31
Our findings highlight the disruption of neuronal-glial communication in tauopathy and suggest that C31 treatment ameliorates aspects of this crosstalk, potentially by directly engaging microglia in addition to its known protective role in synaptic integrity and plasticity. These results provide further insight into C31's mechanism of action and its therapeutic potential for neurodegenerative diseases.
Authors
- Yann Le Guen (ORCID: https://orcid.org/0000-0001-6649-8364)
- Robert R. Butler (ORCID: https://orcid.org/0000-0003-0200-8682)
- Frank M. Longo (ORCID: https://orcid.org/0000-0002-9514-7325)
- Tao Yang (ORCID: https://orcid.org/0009-0000-9654-5440)
- C. J. Han
- Albert Leng (ORCID: https://orcid.org/0000-0001-8049-7624)
- Stephen M. Massa (ORCID: https://orcid.org/0000-0003-0474-4886)
- Kevin C Tran
- Harry Liu
Institutions
- University of California, San Francisco (US)
- Neurosciences Institute (US)
- Stanford Medicine (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_099554
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00