Multi‐omic Immune Cell Phenotypes Associate with Cortical Thickness and Cognition in a Multi‐Ethnic Cohort

In a multi-ethnic cohort of middle-aged adults, we showed that higher naïve CD8+ T cell proportions and reduced expression of cytotoxicity-related genes across T cell subtypes are associated with higher cortical thickness in AD-relevant brain regions, even after adjusting for age. This finding suggests that therapeutic approaches to maintain the naïve T cell pool and target T cell cytotoxicity and clonal expansion may help protect against atrophy in AD-related brain regions and boost cognition in older adults.