Pain after osteoporotic fractures using mouse models and patient samples
This study demonstrates that OVX and subsequent bone loss in mice are insufficient to induce pain behaviours but may intensify pain after fracture. Our clinical analysis does not show a correlation between circulating nerve markers and fracture pain reported by the patients but suggests possible sex differences in pain markers that need to be further investigated.
Authors
- Asim Azfer
- Chantal Chenu (ORCID: https://orcid.org/0000-0002-5727-6070)
- Andreea Radulescu (ORCID: https://orcid.org/0000-0003-0284-8040)
- Mark Hopkinson (ORCID: https://orcid.org/0000-0002-9508-8652)
- S. Ralston
- Y. Chang
Institutions
- Royal Veterinary College (GB)
- Western General Hospital (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Journal of Bone and Mineral Metabolism
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1007/s00774-025-01677-w
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission