Brain connectivity drives tau presence while regional vulnerability drives tau load in Alzheimer's disease
Tau presence follows a Braak-like pattern driven by connectivity, while tau load varies across people based on regional vulnerability. These findings validate known mechanisms but highlight under-explored contributions of receptor distributions to tau accumulation.
Authors
- Lijun An (ORCID: https://orcid.org/0000-0003-1030-4625)
- Vincent Bazinet (ORCID: https://orcid.org/0000-0001-6693-9641)
- Rik Ossenkoppele (ORCID: https://orcid.org/0000-0003-1584-7477)
- Erik Stomrud (ORCID: https://orcid.org/0000-0002-0841-5580)
- Olof T. Strandberg
- Golia Shafiei (ORCID: https://orcid.org/0000-0002-2036-5571)
- Nicola Spotorno (ORCID: https://orcid.org/0000-0001-5404-8788)
- Yu Xiao (ORCID: https://orcid.org/0000-0002-7519-8248)
- Oskar H. Hansson
- Alain Dagher
- Harry H. Behjat
- Justine Hansen
- Sebastian Palmqvist
- Jacob W. Vogel
- Ruben Smith
- Bratislav Misic
- Niklas Mattsson‐Carlgren
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Lund University (SE)
- Science for Life Laboratory (SE)
- McGill University (CA)
- University of Pennsylvania (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70856_100814
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00