Relief from Chronic Unpredictable Mild Stress-Induced Constipation by Fluoxetine and Butyrate and Their Impact on Gut Microecology

FLX alleviates CUMS-induced depression and constipation through restoring serotonin signaling, modulating gut microbiota toward SCFA production, and improving intestinal barrier function. The novel synergistic enhancement achieved by FLX-butyrate combination demonstrates superior therapeutic efficacy, highlighting its potential as an innovative dual-targeting strategy for gut-brain axis disorders.