Regenerative Potential of Extracellular Vesicles on Intervertebral Disc Degeneration: What is the <scp>EV‐idence</scp> ?
Here, we sketch and discuss the consolidated "EV-idence" of EV-mediated IVD tissue regeneration with studies that have specifically included the minimal MISEV requirements, i.e., (1) EV-depletion of serum when supplemented in culture medium and (2) inclusion of EV-depleted conditioned medium as a negative control. Although in several studies, EVs showed homeostatic effects and halted IVD degeneration, solid conclusions are constrained by the limited number of studies complying with the MISEV guidelines.
Authors
- Chantal Voskamp (ORCID: https://orcid.org/0009-0005-8113-2682)
- Marca H. M. Wauben (ORCID: https://orcid.org/0000-0003-0360-0311)
- Marianna A. Tryfonidou (ORCID: https://orcid.org/0000-0002-2333-7162)
- Daniele Corraini
Institutions
- University of Applied Sciences Utrecht (NL)
- Utrecht University (NL)
- University Medical Center Utrecht (NL)
- Regenerative Medicine Institute (MX)
Publication Details
- Journal
- JOR Spine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/jsp2.70149
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Horizon 2020 Framework Programme
- Stichting voor de Technische Wetenschappen