Characterization of Top Protein Candidates in Alzheimer's Disease in Down Syndrome, Early‐Onset, and Late‐Onset AD

Our findings reveal key functional characteristics of the amyloid plaque proteome in DS, compared to EOAD and LOAD, and enhance our understanding of underexplored proteins that play pivotal roles in AD neuropathology beyond Aβ and Tau pathologies. These results could pave the way for follow up mechanistic studies, novel diagnostic biomarkers, and therapeutic strategies in both DS and AD by shedding light on previously understudied proteins.

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Publication Details

Journal
Alzheimer s & Dementia
Published
2025-12-01
DOI
https://doi.org/10.1002/alz70855_105910
Primary Topic
Down syndrome and intellectual disability research
Type
article
Field-Weighted Citation Impact
0.00
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article

Characterization of Top Protein Candidates in Alzheimer's Disease in Down Syndrome, Early‐Onset, and Late‐Onset AD

Orrin Devinsky, Dominique Leitner, Evgeny Kanshin, Mitchell Marta Ariza et al.
Alzheimer s & Dementia
Down syndrome and intellectual disability research
article

Characterization of Top Protein Candidates in Alzheimer's Disease in Down Syndrome, Early‐Onset, and Late‐Onset AD

Orrin Devinsky, Dominique Leitner, Evgeny Kanshin, Mitchell Marta Ariza, Juan M. Fortea, Alberto Lleó, Eleanor Drummond, Beatrix Ueberheide, Thomas Wisniewski
article en

Abstract

Our findings reveal key functional characteristics of the amyloid plaque proteome in DS, compared to EOAD and LOAD, and enhance our understanding of underexplored proteins that play pivotal roles in AD neuropathology beyond Aβ and Tau pathologies. These results could pave the way for follow up mechanistic studies, novel diagnostic biomarkers, and therapeutic strategies in both DS and AD by shedding light on previously understudied proteins.

Alzheimer s & DementiaVol. 21(S1)
Universitat Autònoma de Barcelona (ES), The University of Sydney (AU), Instituto de Salud Carlos III (ES), Hospital de Sant Pau (ES), Biomedical Research Networking Center on Neurodegenerative Diseases (ES), Fundació Catalana per a la Recerca i la Innovació (ES), New York University (US)
Openalex Percentile: Top 26%
Down syndrome and intellectual disability research
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Characterization of Top Protein Candidates in Alzheimer's Disease in Down Syndrome, Early‐Onset, and Late‐Onset AD — Orrin Devinsky, Dominique Leitner, et al. · Alzheimer s & Dementia (2025) | TGRS Research Map | TGRS