Brain transport platform for precision drug delivery of large molecule therapeutics to treat Alzheimer’s disease
We have developed several panels of efficient antibody brain shuttles. The lead anti-hTfR, anti-hCD98hc and anti-Target 3 brain shuttles can be tailored to improve the brain uptake and target engagement of diverse payloads.
Authors
- Donald E. Ingber (ORCID: https://orcid.org/0000-0002-4319-6520)
- Amanda Graveline (ORCID: https://orcid.org/0000-0002-2626-4093)
- J SANTOS
- Yifei Lü (ORCID: https://orcid.org/0000-0001-8907-4898)
- L. Wang
- James Gorman (ORCID: https://orcid.org/0000-0001-9092-7704)
- Daniela Texeira
- Amy England
- Melinda Sanchez
- Teresa Barata
Institutions
- Universidade do Porto (PT)
- Harvard University Press (US)
- Baim Institute for Clinical Research (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70859_102074
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00