Hypercaloric diet modulates hippocampal electrophysiological responses in a rat model of Alzheimer's Disease
The HCHF diet partially rescues AD-related deficits in neuronal activity by restoring baseline power and synchronization, suggesting that the HCHF diet may serve as a metabolic intervention by transiently normalizing neuronal activity in the metabolically-challenged AD brain while being detrimental in normal aging.
Authors
- Margaret M. Koletar (ORCID: https://orcid.org/0000-0003-4464-3887)
- JoAnne McLaurin
- Aaron Y. Lai (ORCID: https://orcid.org/0000-0001-5188-0034)
- Andrea Trevisiol (ORCID: https://orcid.org/0000-0002-7265-3639)
- Dustin Loren V. Almanza
- Dr Bojana Stefanovic
- Greg Stanisz
- Mary Hill
Institutions
- Sunnybrook Health Science Centre (CA)
- University of Toronto (CA)
- Health Sciences Centre (CA)
- Sunnybrook Hospital (CA)
- Sunnybrook Research Institute
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_107129
- Primary Topic
- Regulation of Appetite and Obesity
- Type
- article
- Field-Weighted Citation Impact
- 0.00