Alzheimer's Disease and concomitant pathologies in SuperAgers
Across three national cohorts, SuperAgers with optimal memory performance had fewer neuritic plaques, CAA, and neocortical/medial temporal lobe TDP-43 compared to AD dementia cases and other oldest-old adults with typical memory performance. In contrast, despite their optimal memory performance, SuperAgers had similar levels of cerebrovascular pathology to AD cases and controls.
Authors
- Michael Cuccaro
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- Gary W. Beecham (ORCID: https://orcid.org/0000-0002-7061-6332)
- Emily H. Trittschuh (ORCID: https://orcid.org/0000-0003-0557-1542)
- Derek B. Archer (ORCID: https://orcid.org/0000-0001-8638-0785)
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- Leslie S. Gaynor (ORCID: https://orcid.org/0000-0003-1121-4365)
- Adam C. Naj (ORCID: https://orcid.org/0000-0002-9621-2942)
- William S. Bush (ORCID: https://orcid.org/0000-0002-9729-6519)
- Brandon S. Klinedinst (ORCID: https://orcid.org/0000-0003-2697-1852)
- Pedro Mena (ORCID: https://orcid.org/0000-0003-2150-2977)
- Phoebe Scollard
- Eden R. Martin (ORCID: https://orcid.org/0000-0002-4035-9152)
- Badri Narayan Vardarajan (ORCID: https://orcid.org/0000-0002-5560-4085)
- Alaina Durant
- Lisa Laverne Barnes
- Seo‐Eun Choi (ORCID: https://orcid.org/0000-0002-2163-688X)
- Lindsay AA. Farrer
- Andrew Joel Saykin
- Li‐San Wang
- Walter W. Kukull
- Margaret Pericak‐Vance
- Carlos Cruchaga
- Jonathan L Haines
- Paul K Crane
- Thomas J. Montine
- Shubhabrata Mukherjee
- C. Dirk Keene
- Brian W Kunkle
- Julie A Schneider
- Jesse Mez
- David A. A. Bennett
- Richard Mayeux
- Michael L. Lee
- Paul M. Thompson
Institutions
- Boston University (US)
- University of Southern California (US)
- Rush University Medical Center (US)
- NewYork–Presbyterian Hospital (US)
- University of Miami (US)
- Vanderbilt University (US)
- University of Washington (US)
- Washington University in St. Louis (US)
- Columbia University Irving Medical Center (US)
- VA Puget Sound Health Care System (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- Dr. John T. Macdonald Foundation (US)
- Indiana University School of Medicine
- Wake Forest University (US)
- Indiana University – Purdue University Indianapolis (US)
- Case Western Reserve University (US)
- University of Pennsylvania (US)
- Vanderbilt University Medical Center (US)
- Stanford University (US)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz70855_106764
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00