<i>Parasutterella excrementihominis</i> exacerbates experimental colitis and colitis-associated colorectal cancer via pathogenic NETosis activation
Our findings identify <i>P. excrementihominis</i> as a critical microbial driver of UC and CAC pathogenesis. This bacterium significantly accelerates disease progression by producing specific metabolites (Suc and 6-HHA) that induce pathogenic NETosis. Targeting this bacterium or its metabolic axis offers novel therapeutic strategies for inflammation-driven colorectal carcinogenesis.
Authors
- Linwen Huang
- Jun Wang (ORCID: https://orcid.org/0000-0002-6346-2929)
- Haiyan Zhang (ORCID: https://orcid.org/0000-0002-0379-0939)
- Siqi Yang
- H M Huang
- Huishi Tan
- Zelong Lin
- Jierui Li
- Yongjian Zhou
- Chongyang Huang
- Yanqiang Shi
Institutions
- Guangzhou University of Chinese Medicine (CN)
- State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Institute of Dermatology (CN)
- Guangdong Provincial People's Hospital (CN)
- Guangdong Provincial Family Planning Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Gut
- Published
- 2025-12-25
- DOI
- https://doi.org/10.1136/gutjnl-2025-335887
- Citations
- 2
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.59